Odborná literatura

Sysmex Educational Enhancement and Development July 2012

Sysmex Educational Enhancement and Development February 2013

Sysmex Educational Enhancement and Development April 2014

The treatment of immune thrombocytopenia (ITP) can be challenging. The immature platelet count (IPF) can be used in ITP as a supportive information to assess whether the treatment mechanism is having an effect: To have a supportive parameter to answer the clinical question as to whether the observed increase in the platelet count is due to increased platelet production or inhibition of antibody-mediated platelet destruction. Due to the higher reactivity and haemostatic potential of immature platelets, an increased immature platelet count was also found to be associated with a lower risk of bleeding with severely thrombocytopenic patients.

A short introduction to the concepts of metrological traceability and measurement uncertainty is given in the article for readers who are not familiar with them. It also includes a short description of the steps needed to evaluate uncertainty. The article further explains how traceability is assured for the Sysmex haematology calibrators and describes how the uncertainty of these calibrators was evaluated.

This SEED article is meant to explain the findings focused on cell count and differentiation for pleural, ascitic, cerebrospinal and synovial fluid as well as for CAPD. Traditionally, body fluid counts are performed by manual counting under a microscope using a haemocytometer, but laboratories now have the option of automating their manual processes using automated haematology or urinalysis analysers. This SEED summarises the advantages and disadvantages of haemocytometry and Sysmex analysers and explains briefly the XN-BF mode.

The fluorescence technology and channel-specific reagents of the XN-Series provide much more than just a cell count. Depending on their cell membrane composition, cells are perforated and labelled differently, disclosing information about the cells’ activity, maturity stage, and malignancy. This white paper sheds a light on how the XN measures cell functionality.