Odborná literatura

The first part of this SEED article informs about haematopoietic stem cells, their aetiology and sources as well as the clinical background of haematopoietic stem cell transplantation (HSCT).

By combining the WDF and WPC measurement channels the sensitivity and specificity for detecting reactive and malignant cells can be optimised. The measurement technology of XR-Series or XN-Series analysers detect the white blood cell functionality and the ‘Extended Inflammation Parameters’ let you quantify the activation status of lymphocytes and neutrophils, and the results can be applied once a malignant condition of the patient has been excluded.

In this case report a case of suspected nontuberculous mycobacterial (NTM) lung disease is described. The XR-Series Body Fluid (BF) mode showed two mononuclear cell populations in a pleural effusion sample.

Synovial fluid is a viscous liquid found in the cavities of synovial joints. Several articular diseases are characterised by fluid accumulation in joints, so that arthrocentesis and morphological analysis are essential tools for differentiating a non-inflammatory arthropathy from an inflammatory arthropathy or an infectious disease. Cell count and differentiation are important diagnostic aspects in such patients. This first SEED article about synovial fluid summarises the typical characteristics and recommends procedures for specimen collection and handling.

The determination of the ‘erythrocyte sedimentation rate’ (ESR) is a commonly performed laboratory test with a traditional role. In this article, the mechanism of red blood cell aggregation and sedimentation is described, the standardised procedure is explained and we provide an update on the clinical interpretation of the ESR.

The term ‘NRBC’ – ‘nucleated red blood cells’ – refers to precursor cells of the red blood cell lineage which still contain a nucleus. In healthy adults and older children, NRBC can only be found in blood-building bone marrow where they mature. Their appearance in peripheral blood points to extramedullary erythropoiesis or disruption of the blood - bone marrow barrier. Both possible scenarios can only be found in the course of a severe disease.

Sysmex Educational Enhancement and Development January 2016 The importance of reticulocyte detection

Thrombocytopenia is a disorder in which there is an abnormally low amount of platelets. It can be life threatening and its detection and precise count is extremely important. The immature platelet fraction (IPF parameter) measures young, reticulated platelets in peripheral Blood, revealing if the bone marrow is producing or not.

Sysmex Educational Enhancement and Development March 2014