RD-210

Nodal status matters

More differentiated information – Supporting better treatment decisions

Lymph node status is one of the most important prognostic factors in many cancers and a key criterion for surgical and therapeutic decisions. Analysing lymph node tissue reliably and accuracy is therefore crucial for detecting metastases.

Routine practice in histopathology analyses only a limited amount of tissue and therefore provides only limited information, which might not reflect the real metastatic burden.

OSNA – One Step Nucleic Acid Amplification – is an automated molecular diagnostic assay that analyses the entire lymph node tissue. The reaction is based on rapid nucleic acid amplification technology (RT-LAMP*) to quantify Cytokeratin 19 (CK19) mRNA expression. CK19 is an epithelial cell marker and is not normally present in lymph node tissue. The expression rate of CK19 mRNA correlates with the size of the metastatic foci.